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. Author manuscript; available in PMC: 2016 May 1.
Published in final edited form as: Chem Biol Drug Des. 2014 Nov 18;85(5):549–564. doi: 10.1111/cbdd.12443

Table 1.

a Biochemical potency data for analogs of 3.

graphic file with name nihms-633066-t0007.jpg
Compound R1 X TbrPDEB1
(% inh)		 TbrPDEB1
(IC50 μM)		 TbrPDEB2
(IC50 μM)
3 CONMe2 SO2 51 ± 3.9 24 ±1.7 29.8 ± 7.5
9a CO2Me S 12 ±6.1 - -
9b H S 10.0b
10a CO2Me SO2 70 ± 7.9 3.5 ± 0.3 15.1 ± 3.9
10b H SO2 21 ± 16 - -
11 CO2H SO2 82 ± 10 2.9 ± 0.8 6.8 ± 0.6
12a CONH2 SO2 64 ± 7 - -
12b CONHMe SO2 66 ± 6.1 31 ± 5.8 -
13 CO2Me NH 84 ± 7.7 16 ± 1.7 -
a

All values are the mean of three or more replicates ± SEM.

b

n=1