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a Exploring Regions C and D of 19.
| Compound | R3 | R4 | TbrPDEB1 (% inh) |
TbrPDEB1 (IC50 μM) |
|---|---|---|---|---|
| 19a | Me | NH2 | 84 ± 9.1 | 3.1 ± 0.5 |
| 19b | H | NH2 | 84 ± 2.4 | 12 ± 1.3 |
| 19c | Et | NH2 | 79 ± 8.9 | 3.7 ± 0.5 |
| 27a | Me | NHCH3 | 34 ±11 | - |
| 27b | Me | NMe2 | 22 ± 3.8 | - |
All values are the mean of three or more replicates ± SEM.
