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. Author manuscript; available in PMC: 2016 Jun 1.
Published in final edited form as: J Membr Biol. 2014 Oct 4;248(3):383–394. doi: 10.1007/s00232-014-9734-0

Fig. 7.

Fig. 7

pH-dependence of the free energy of interfacial membrane binding (90PC/10PG, olive) and transmembrane insertion (75PC/25PG, red; 25PC/75PG, blue) for the diphtheria toxin T-domain WT. The free energy of binding to lipid vesicles with formation of trapped interfacial intermediate state is close to −8 kcal/mole, and is pH-independent. The free energy difference between the transmembrane T-state and the interfacial I-state ranges from −1.5 to −4 kcal/mol depending on membrane composition and the pH.