Table 1.

Quantitative expression of insulin-like growth factor-1 mRNA isoforms, total mRNA insulin-like growth factor-1, and insulin-like growth factor-1R mRNA (mean ± SD) normalized in relation to housekeeping genes in chronic hepatitis C and in control organ

mRNA	Control (n = 7)	CH-C (n = 34)	P value	CH-C		P value
				Women (n = 16)	Men (n = 18)
class 1 (P1)	0.19 ± 0.21	0.45 ± 0.45	P = 0.025	0.63 ± 0.59	0.28 ± 0.17	P = 0.003
class 2 (P2)	0.08 ± 0.07	0.15 ± 0.17	P = 0.164	0.20 ± 0.15	0.11 ± 0.18	P = 0.006
IGF-1A	1.30 ± 1.31	5.28 ± 9.94	P = 0.009	7.88 ± 13.83	2.97 ± 3.32	P = 0.027
IGF-1B	0.18 ± 0.18	0.28 ± 0.40	P = 0.486	0.35 ± 0.45	0.22 ± 0.35	P = 0.042
IGF-1C	0.04 ± 0.05	0.21 ± 0.57	P = 0.031	0.35 ± 0.82	0.08 ± 0.06	P = 0.046
Total IGF-1	1.52 ± 1.52	5.77 ± 10.85	P = 0.014	8.58 ± 15.09	3.26 ± 3.70	P = 0.027
IGF-1R	0.26 ± 0.18	0.14 ± 0.04	P = 0.016	0.14 ± 0.05	0.14 ± 0.04	P = 0.295

IGF-1: Insulin-like growth factor 1; CH-C: Chronic hepatitis C.