Table 2.

Tissue expression of insulin-like growth factor-1 mRNA isoforms and insulin-like growth factor-1R mRNA (mean ± SD) as related to grading and staging in hepatitis C virus-infected livers

mRNA	Grading1 1 (n = 15)	Grading 2 (n = 16)	P value	Staging1 1 (n = 21)	Staging 2 (n = 8)	P value
class 1 (P1)	0.63 ± 0.61	0.33 ± 0.20	P = 0.037	0.50 ± 0.55	0.41 ± 0.23	P = 0.905
class 2 (P2)	0.25 ± 0.22	0.09 ± 0.06	P = 0.009	0.19 ± 0.20	0.11 ± 0.07	P = 0.549
IGF-1A	8.67 ± 14.34	2.42 ± 1.45	P = 0.008	6.55 ± 12.47	3.01 ± 1.77	P = 0.943
IGF-1B	0.44 ± 0.55	0.15 ± 0.10	P = 0.012	0.34 ± 0.49	0.18 ± 0.12	P = 0.720
IGF-1C	0.36 ± 0.84	0.08 ± 0.06	P = 0.093	0.27 ± 0.72	0.09 ± 0.07	P = 0.582
Total IGF-1	9.47 ± 15.66	2.65 ± 1.58	P = 0.006	7.16 ± 13.61	3.29 ± 1.91	P = 0.830
IGF-1R	0.12 ± 0.04	0.16 ± 0.03	P = 0.025	0.14 ± 0.04	0.16 ± 0.04	P = 0.198

¹Parameters evaluated in a semi-quantitative scale (see Material and Methods). IGF-1: Insulin-like growth factor 1.