Table 1.
Review of cases of malignant formation arising from a heterotopic pancreas in the duodenum
| Case | Year | Author | Age (yr) | Sex | Clinial symptoms | Location | Preoperative diagnosis | Diagnostic approach | Size (mm) | Pathology | Heinrich | Outcome |
| 1 | 1993 | Tanaka | 72 | M | Abdominal pain | D (ND) | ND | Operation | 12 | Cancer | ND | ND |
| 2 | 1996 | Inoue | 81 | F | Anorexia | D (ND) | Duodenal cancer | Biopsy | 25 | pap + muc | I | ND |
| 3 | 2006 | Inoue | 75 | M | Melena | D (ND) | No evidence of malignancy | Operation | 20 | tub | III | ND |
| 4 | 2007 | Tison | 72 | M | Abdominal pain, jaundice | D (2nd; Vater) | Tumor of the ampulla of Vater | Biopsy | ND | Adenocarcinoma, CDHP | ND | Death (16 mo) |
| 5 | 2007 | Kawakami | 68 | F | Jaundice | D (2nd; Vater) | Carcinoma of the ampulla of Vater | Biopsy | 12 | Acinar cell carcinoma | ND | Not death (19 mo) |
| 6 | 2008 | Rosok | 59 | F | No symptom | D (proximal) | No evidence of malignancy | Operation | 50 | IPMC | ND | Not death (36 mo) |
| 7 | 2010 | Inoue | 75 | M | Nausea, vomiting | D (2nd) | Cancer, GIST, MTL | Operation | ND | tub (well) | III | Not death (72 mo) |
| 8 | 2010 | Bini | 56 | M | Vomiting | D (1st) | Adenocarcinoma of uncertain origin | Biopsy | ND | Adenocarcinoma | I | ND |
| 9 | 2011 | Stock | 79 | F | Abdominal fullness, | D (4th) | No evidence of malignancy | Operation | 30 | Adenocarcinoma | I | ND |
| intermittent abdominal pain | ||||||||||||
| 10 | 2012 | Kinoshita | 62 | F | Vomiting, epigastralgia | D (1st) | Gastric cancer | Operation | 34 | tub (mode) | I | Not death (12 mo) |
| 11 | 2013 | Ginori | 86 | F | Abdominal pain, nausea, | D (1st) | Acute cholecystitis | Operation | 30 | well + muc + por | I | ND |
| vomiting | ||||||||||||
| 12 | 2014 | Endo | 75 | M | Epigastric pain, tarry stool | D (2nd) | Adenocarcinoma of uncertain origin | EUS-FNA | 22 | por | I | Not death (60 mo) |
| 13 | Present case | 62 | M | Weihgt loss | D (3rd) | Suspected duodenal cancer | Operation | 15 | tub (mode) | IV | Death (33 mo) | |
ND: Not described; GIST: Gastrointestinal stromal tumor; MTL: Malignant lymphoma; EUS-FNA: Endoscopic ultrasonography-guide fine-needle aspiration; tub: Tubular adenocarcinoma; well: Well differentiated type; mode: Moderately differentiated type; por: Poorly differentiated adenocarcinoma; pap: Papillary adenocarcinoma; muc: Mucinous carcinoma; CDHP: Cystic dystrophy in heterotopic pancreas; IPMC: Intraductal papillary-mucinous carcinoma.