TABLE 6.
SarA-regulated genes differentially expressed in a biofilm
| N315 ORFa | Common namea | Producta,b | B/Ec | B/Sc | SarAd |
|---|---|---|---|---|---|
| N315-SAS016 | HP | 12.74 | Up | ||
| N315-SA2425 | arcC | Carbamate kinase | 37.87 | 5.76 | Down |
| N315-SA2424 | arcR | Transcription regulator Crp/Fnr family protein | 48.16 | 9.87 | Down |
| N315-SA2321 | HP | 0.33 | Up | ||
| N315-SA2319 | sdhB | Similar to beta: subunit of l-serine dehydratase | 8.90 | 4.84 | Up |
| N315-SA2125 | hutG | Similar to formiminoglutamase | 0.35 | Up | |
| N315-SA2006 | Similar to MHC class II analog | 4.69 | Up | ||
| N315-SA1928 | HP | 0.42 | Up | ||
| N315-SA1611 | CHP | 0.23 | Up | ||
| N315-SA1553 | fhs | Formyltetrahydrofolate synthetase | 0.17 | Down | |
| N315-SA1516 | phoP | Alkaline phosphatase synthesis | 0.48 | Up | |
| N315-SA1381 | pbp3 | Penicillin-binding protein 3 | 0.48 | Down | |
| N315-SA1319 | HP | 0.42 | Up | ||
| N315-SA1140 | glpF | Glycerol uptake facilitator | 4.40 | Down | |
| N315-SA1120 | Similar to transcription regulator GntR family | 0.35 | Up | ||
| N315-SA1045 | carA | Carbamoyl-phosphate synthase small chain | 13.13 | 6.03 | Up |
| N315-SA0923 | purM | Phosphoribosylformylglycinamidine cyclo-ligase | 0.34 | 0.03 | Down |
| N315-SA0900 | sspB | Cysteine protease precursor | 7.03 | Down | |
| N315-SA0899 | sspC | Cysteine protease | 7.24 | Down | |
| N315-SA0754 | Similar to lactococcal prophage ps3 protein 05 | 0.50 | Up | ||
| N315-SA0746 | nuc | Staphylococcal nuclease | 0.17 | Down | |
| N315-SA0412 | CHP | 0.08 | Down | ||
| N315-SA0411 | ndhF | NADH dehydrogenase subunit 5 | 0.07 | 2.41 | Down |
| N315-SA0363 | HP | 0.32 | Down | ||
| N315-SA0107 | spa | Immunoglobulin G-binding protein A precursor | 0.01 | 0.04 | Down |
| N315-SA0016 | purA | Adenylosuccinate synthase | 2.37 | 0.12 | Up |
| fnbB | Fibronectin-binding protein homolog | 0.46 | Up |
a
Based on the published sequence of S. aureus strain N315. For genes not present in N315, the gene name and description given are from the S. aureus strain COL genome, available from The Institute for Genomic Research website (www.tigr.org or by the putative function.
b
Abbreviations: HP, hypothetical protein; CHP, conserved hypothetical protein.
c
Normalized values based on expression levels in biofilms versus exponential-phase cells (B/E) or biofilms versus stationary-phase cells (B/S).
d
Regulation by SarA as reported by Dunman et al. (19).