Table 2.
Univariate and multivariate analyses for variables significantly associated with subsequent bladder recurrence after RNU in 532 patients with UUT-UC.
| Variable | Univariate | Multivariate | ||
|---|---|---|---|---|
| HR (95% CI) | P | HR (95% CI) | P | |
| Age (years) | ||||
| <65 | 1 | — | ||
| ≥65 | 0.819 (0.594–1.128) | 0.222 | ||
| Gender | ||||
| Female | 1 | — | ||
| Male | 1.210 (0.878–1.669) | 0.245 | ||
| Smoking | ||||
| No | 1 | — | ||
| Yes | 1.221 (0.838–1.778) | 0.298 | ||
| BMI | 0.967 (0.909–1.028) | 0.277 | ||
| eGFR (mL/min) | ||||
| <60 | 1 | — | ||
| >60 | 1.347 (0.757–2.396) | 0.312 | ||
| Hemodialysis | ||||
| No | 1 | — | 1 | — |
| Yes | 1.603 (0.990–2.595) | 0.055 | 1.791 (0.988–3.244) | 0.055 |
| Chinese herbal medicine use | ||||
| No | 1 | — | 1 | — |
| Yes | 1.851 (1.012–3.386) | 0.046* | 1.387 (0.731–2.632) | 0.316 |
| Hypertension | ||||
| No | 1 | — | ||
| Yes | 1.292 (0.868–1.922) | 0.207 | ||
| DM | ||||
| No | 1 | — | 1 | — |
| Yes | 1.953 (1.241–3.074) | 0.004* | 1.821 (1.152–2.878) | 0.010* |
| Residency | ||||
| Nonarsenic | 1 | — | ||
| Arsenic | 0.775 (0.247–2.434) | 0.662 | ||
| OP method | ||||
| Transperitoneal | 1 | — | ||
| Retroperitoneal | 1.097 (0.674–1.786) | 0.708 | ||
| OP method | ||||
| Open | 1 | — | ||
| Laparoscopy | 1.420 (0.868–2.323) | 0.162 | ||
| Grade | ||||
| Low | 1 | — | ||
| High | 0.994 (0.705–1.402) | 0.974 | ||
| Ureteral involvement | ||||
| No | 1 | — | 1 | — |
| Yes | 1.639 (1.189–2.260) | 0.003* | 1.838 (1.233–2.741) | 0.003* |
| Multiplicity | ||||
| No | 1 | — | ||
| Yes | 1.499 (0.953–2.356) | 0.080 | ||
| T stage | ||||
| Ta, 1 | 1 | — | ||
| T2 | 1.135 (0.727–1.771) | 0.578 | ||
| T3, 4 | 0.914 (0.610–1.368) | 0.661 | ||
| Tis | 2.110 (0.770–5.785) | 0.147 | ||
| N stage | ||||
| N0 | 1 | — | ||
| N1, 2, 3 | 0.394 (0.125–1.239) | 0.111 | ||
BMI: body mass index, DM: diabetes mellitus, HR: Hazard ratio, and CI: confidence interval.
*Significant difference, P < 0.05.