Table 3.

Descriptive information about adolescents with MDD and HC participants stress functioning

Characteristics	Total Sample M (SD)	MDD All M (SD)	MDD Med M (SD)	MDD No Med M (SD)	HC M(SD)
Behavioral index of stress (N = 74)
TSST ratings (z score)	0.00 ± 0.85	0.29 ± 0.77	0.27 ± 0.90	0.30 ± 0.72	−0.54 ± 0.72
Amygdala structure (N = 79)
Right amygdala volume	1693.65 ± 221.12	1675.05 ± 203.03	1717.78 ± 169.97	1656.06 ± 215.60	1729.49 ± 252.57
Left amygdala volume	1583.84 ± 191.76	1583.05 ± 177.32	1604.10 ± 169.37	1573.69 ± 182.28	1584.38 ± 220.54
Amygdala function, emotion   matching task (N = 66)
Right amygdala	0.77 ± 0.84	0.93 ± 0.81	0.84 ± 0.82	0.98 ± 0.82	0.43 ± 0.80
Left amygdala	1.52 ± 0.56	1.62 ± 0.60	1.60 ± 0.55	1.62 ± 0.62	1.31 ± 0.49
HPA axis functioning
TSST AUCg (N = 74)	19.39 ± 13.89	19.97 ± 14.74	17.75 ± 10.42	21.08 ± 16.53	18.32 ± 12.36
TSST AUCi (N = 74)	1.28 ± 11.51	0.08 ± 12.09	−1.64 ± 14.06	0.94 ± 11.12	3.49 ± 10.21
MRI CORT difference (N = 69)	−0.02 ± 0.20	0.00 ± 0.20	0.03 ± 0.18	−0.01 ± 0.21	−0.07 ± 0.19

Note: MDD, Major depressive disorder; HC, healthy control; Med, medicated; No Med, not medicated; HPA, hypothalamic–pituitary–adrenal axis; TSST, Trier Social Stress Test; AUCg, area under the curve ground levels of salivary cortisol; AUCi, area under the curve initial levels of salivary cortisol; MRI, magnetic resonance imaging; MRI CORT difference, pre-MRI – post-MRI levels of salivary cortisol.