Table 1.

Enantioselective desymmetrization via CAHB.

entry	5	R1	R2	yielda	er/drb
1	a	H	Ph	80	97:3
2	b	Me	Ph	65	96:4
3	c	Ph	Ph	72	96:4
4	d	CF3	Ph	78	97:3
5	e	H	Bn	69	94:6
6	f	Me	Bn	62	92:8
7	g	Ph	Bn	70	93:7
8	h	CF3	Bn	71	96:4
9c	i	Ph	(R)-CH(Me)Ph	76	88:12
10c	j	Ph	(S)-CH(Me)Ph	74	20:80

^aIsolated yields, an average of three experiments generally exhibiting a spread of ±2%.

^bEnantiomer ratio (er) determined by chiral HPLC analysis or diastereomer ratio (dr) determined by ¹H NMR.

^c2% catalyst loading.