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. Author manuscript; available in PMC: 2015 Apr 5.
Published in final edited form as: Science. 2014 Dec 12;346(6215):1256846. doi: 10.1126/science.1256846

Fig. 3. Relative number of genes with significantly shared specialized expression between avian and human brain regions.

Fig. 3

Each panel shows a plot of the number of genes significantly specialized (P < 0.05; hypergeometric test) in common between the avian and human samples relative to the number of genes expected to be specialized by chance. (A) Finch Area X + VS specialization compared to all subregions of the human telencephalon. (B) Finch pallial region (RA, neighboring arcopallium, HVC, and LMAN combined) specialization compared to all subregions of the human telencephalon. (C) Finch Area X specialization compared to all subregions of the human striatum. (D) Finch RA specialization compared to the specialization of every subregion from the human cortex, which optimally aligned to the zebra finch pallium. (E) Avian RA analogs (vocal learners) and mAC (nonlearners) relative to the adjacent arcopallium compared to human LMC/dLSC relative to cortex. (F) Avian RA analogs (vocal learners) and mAC (nonlearners) relative to the arcopallium compared to human LMC/dLSC relative to PrG/PoG. (G) Avian arcopallium versus whole brain specialized genes compared to human cortex versus whole brain specialized genes. In (A) to (D), asterisks denote the human specializations determined to be similar to the avian specialization on the basis of the optimal alignment and correlation. In (E) to (G), P values less than 0.05 indicate that the number of specialized genes is greater than chance according to a hypergeometric test.