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. 2015 Jan 24;6(4):1967–1980. doi: 10.18632/oncotarget.2806

Figure 4. HIF-1α is sufficient to induce lapatinib-resistance in ERBB2-expressing cells under normoxic conditions.

Figure 4

(A) Cell lysates from cells placed in hypoxia, treated with DMOG for 6 hrs, or cells expressing control or HIF-1α mutant (P402A/P564A) were collected for immunoblot analysis. (B) MCF10A-ERBB2 cells stably expressing control or HIF-1α mutant were treated with increasing doses of lapatinib and cell viability was assessed. (C) Cells as in B were stained with crystal violet. (D) Cell lysates were collected from cells as in B for immunoblot analysis. Error bars indicate S.E. (*p ≤ 0.05).