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. 2014 Dec 12;6(4):2088–2100. doi: 10.18632/oncotarget.2992

Figure 1. MLN0128 is mainly cytostatic in human B-ALL cells.

Figure 1

(A) Cell lines (p190, SUP-B15) or (B) primary B-ALL cells (n = 3 independent specimens) were cultured for 48hr with vehicle or with RAP or MLN0128. The percent viable cells was measured by 7-AAD staining and flow cytometry. For the primary patient samples, cells were grown on stromal cells and viability was determined for human CD19+ cells. (C) DNA content analysis was used to assess cell cycle distribution in p190 and SUP-B15 cells after 48 of culture. * p < 0.05; ** p < 0.01, *** p<0.001, one-way ANOVA.