Skip to main content
. 2014 Dec 12;6(4):2088–2100. doi: 10.18632/oncotarget.2992

Figure 4. B-ALL cell death is caspase-dependent.

Figure 4

(A) SUP-B15 cells were cultured with MLN0128 (100 nM), vorinostat (500 nM), or the combination (M + V) in the presence of increasing concentrations of pan-caspase inhibitor. The percentage of cell death was determined after 48 hr by 7-AAD staining (mean +/− SEM, n = 3-5). * p < 0.05; ** p < 0.01, two-way ANOVA. (B) PARP cleavage in BV173 cells was measured by western blotting of lysates at various times after addition of MLN0128 (100 nM) and vorinostat (500 nM). Cells treated with the BCL2/BCL-XL antagonist ABT-263 were used as a positive control. β-actin served as a loading control. Similar results were observed in SUP-B15 cells.