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. 2014 Dec 12;6(4):2088–2100. doi: 10.18632/oncotarget.2992

Figure 6. BH3 profiling assay shows increased mitochondrial priming in B-ALL cells treated with MLN0128/vorinostat.

Figure 6

Two Ph+ (SUP-B15 and BV173) and two non-Ph (BLIN-1 and Kasumi-2) B-ALL cell lines were subjected to BH3 profiling assay 16hr after treatment with vehicle (labeled untreated), MLN0128 (100 nM), vorinostat (500 nM), or the combination. Increase in mitochondrial depolarization is a quantitative measure of mitochondrial apoptosis initiation. In all lines, the combination increases the cells, sensitivity to pro-apoptotic BH3 peptides more than either agent alone. Percent depolarization of cells by each peptide is graphed. (mean +/− SD). n = 3-5; *p-value < 0.05; paired one-tailed t-test.