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. 2014 Dec 10;6(4):2235–2249. doi: 10.18632/oncotarget.2946

Figure 3. The effect of βIII-tubulin silencing on pancreatic cancer cell clonogenic capacity.

Figure 3

A-C) Bars represent the number of MiaPaCa-2 colonies (mean±s.e.m. as a % of mock) that formed from low density seeding following transfection with mock, control siRNA (ns-siRNA), or βIII-tubulin siRNA (βIII-Tub siRNA) and 72h culture in titrations of Gemcitabine (A), Paclitaxel (B) or Vincristine (C). D-F) as per A-C, except experiments were carried out with HPAF-II cells. Asterisks indicate significance relative to ns-siRNA of the same drug dose (*** p≤0.001, **** p≤0.0001; n=5). Hashes indicate significance relative to 0 nM drug concentration of the same siRNA (# p≤0.05, ## p≤0.01, #### p≤0.0001; n=5).