Figure 1. PKM2 is significantly increased in HCC.

(A) The expression levels of PKM2 were measured by quantitative real-time PCR in 129 tumor and adjacent non-tumor liver tissues (left). The expression levels of PKM2 in the TCGA are also presented (right). Data are depicted as log₂ of the RPKM (read per kilo bases per million reads). (B) Protein levels of PKM2 and TRIM35 in 14 representative HCC tissues (T) and adjacent non-tumor liver tissues (N) were analyzed by western blotting. (C) Two representative cases of PKM2 and TRIM35 expression are shown for HCC tissues and adjacent non-tumor liver tissues. Original magnification, ×400.