Table 2. Associations between NSCLC risk and individual SNPs involved in the vitamin D pathway.
| Genotype | Number of subject (%) | P | ORa(95%CIb) | ORa(95%CIb) ②+③ vs. ① |
ORa(95%CIb) ③ vs. ①+② |
|
|---|---|---|---|---|---|---|
| Case (n=603) | Control (n=661) | |||||
| CYP27B1 (rs3782130) | ||||||
| CC | 229(38.0) | 230(34.8) | 0.022 | 1.00 | 1.00 | 1.00 |
| CG | 297(49.3) | 371(56.1) | 0.82(0.63-1.06) | 0.90(0.70-1.15) | 1.60(1.09-2.34) | |
| GG | 77(12.8) | 60(9.1) | 1.42(0.94-2.14) | |||
| CYP27B1 (rs10877012) | ||||||
| TT | 235(39.0) | 243(36.8) | 0.331 | 1.00 | 1.00 | 1.00 |
| TG | 273(45.3) | 326(49.4) | 0.87(0.67-1.13) | 0.92(0.72-1.17) | 1.19(0.85-1.66) | |
| GG | 94(15.6) | 91(13.8) | 1.10(0.76-1.58) | |||
| CYP24A1 (rs6068816) | ||||||
| CC | 217(36.0) | 110(16.6) | <0.001 | 1.00 | 1.00 | 1.00 |
| CT | 314(52.1) | 465(70.3) | 0.33(0.25-0.44) | 0.34(0.26-0.45) | 0.87(0.61-1.24) | |
| TT | 72(11.9) | 86(13.0) | 0.40(0.26-0.60) | |||
| CYP24A1 (rs4809957) | ||||||
| GG | 234(38.8) | 228(34.5) | <0.001 | 1.00 | 1.00 | 1.00 |
| GA | 309(51.2) | 406(61.4) | 0.77(0.60-0.99) | 0.88(0.69-1.12) | 2.71(1.66-4.41) | |
| AA | 60(10.0) | 27(4.1) | 2.32(1.40-3.87) | |||
| VDR (rs11574129) | ||||||
| TT | 339(56.2) | 378(57.2) | 0.873 | 1.00 | 1.00 | 1.00 |
| TC | 254(42.1) | 274(41.5) | 1.06(0.84-1.35) | 1.07(0.84-1.36) | 1.36(0.50-3.70) | |
| CC | 10(1.7) | 9(1.4) | 1.39(0.51-3.81) | |||
| GC (rs7041) | ||||||
| TT | 329(54.6) | 272(41.1) | <0.001 | 1.00 | 1.00 | 1.00 |
| TG | 240(39.8) | 339(51.3) | 0.59(0.46-0.76) | 0.59(0.46-0.75) | 0.73(0.46-1.18) | |
| GG | 34(5.6) | 50(7.6) | 0.57(0.35-0.93) | |||
| CYP2R1 (rs10741657) | ||||||
| GG | 252(41.9) | 246(37.2) | 0.216 | 1.00 | 1.00 | 1.00 |
| GA | 270(44.9) | 326(49.3) | 0.82(0.64-1.06) | 0.83(0.65-1.06) | 0.96(0.68-1.36) | |
| AA | 80(13.3) | 89(13.5) | 0.86(0.59-1.25) | |||
| Number of risk-allele | ||||||
| 0 | 138(22.9) | 299(45.2) | 1.00 | |||
| 1 | 282(46.8) | 267(40.4) | 2.46(1.86-3.25) | |||
| 2 | 147(24.4) | 83(12.6) | 4.25(2.96-6.12) | |||
| 3 | 35(5.8) | 12(1.8) | 5.80(2.84-11.84) | |||
a
OR: Odds Ratio adjusted by age, sex, family history of cancer and BMI.
b
CI: Confidence Interval.
① Homozygous wild genotype, ② heterozygous genotype, ③ homozygous variant genotype