Table 3. Associations between NSCLC risk and SNPs by smoking status.
| Genotype | Non-smoker | Smoker | ||||
|---|---|---|---|---|---|---|
| Cases (%) | Controls (%) | ORa(95%CIb) | Cases (%) | Controls (%) | ORa(95%CIb) | |
| CYP27B1 (rs3782130) | ||||||
| CC+CG | 170(84.2) | 338(88.5) | 1.00 | 356(88.8) | 263(94.3) | 1.00 |
| GG | 32(15.8) | 44(11.5) | 1.38(0.83-2.30) | 45(11.2) | 16(5.7) | 1.91(1.04-3.53) |
| P Value | 0.140 | 0.014 | ||||
| CYP24A1 (rs4809957) | ||||||
| GG+GA | 181(89.6) | 364(95.3) | 1.00 | 362(90.3) | 270(96.8) | 1.00 |
| AA | 21(10.4) | 18(4.7) | 2.33(1.20-4.53) | 39(9.7) | 9(3.2) | 3.49(1.63-7.47) |
| P Value | 0.009 | 0.001 | ||||
a
OR: Odds Ratio adjusted by age, sex, family history of cancer and BMI.
b
CI: Confidence Interval.