Fig. 2.

Effects of spaceflight on contractile responses to thromboxane receptor agonist U46619 in basilar arteries from HC, VC, and 30-d Bion-M1 SF mice. A: concentration-active tension relations of basilar arteries to U46619. B: concentration-response relations in the presence of Rho-kinase inhibitor Y27632 (1 μM). Inhibition of Rho-kinase led to significant reduction of contractile responses and eliminated the between-group differences. Values are means ± SE; n = number of animals studied. *P < 0.05 between groups.