Fig. 11.

AdipoR1 levels increase in human colonic biopsies during IBD, and adiponectin reduces cytokine mRNA expression in human NCM460 colonocytes. A: immunohistochemistry of human colonic sections shows elevated levels of AdipoR1 during IBD compared with non-IBD controls. Human colonic epithelial NCM460 cells were exposed to 10 ng/ml adiponectin for 24 h in the medium, and the mRNA levels were determined using a multiplex assay (42-plex). B–G: IL-2, IL-5, IL-2, IL-17, IL-23, and transforming growth factor (TGF)-β2 mRNA levels were significantly reduced in adiponectin-treated NCM460 colonocytes compared with untreated controls. H: mRNA levels of VEGFA were significantly increased. *P < 0.05, **P < 0.01.