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. 2015 Mar 5;6(3):1676. doi: 10.1038/cddis.2015.37

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Copyright © 2015 Macmillan Publishers Limited

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International Licence. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons licence, users will need to obtain permission from the licence holder to reproduce the material. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0

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Increased endogenous RanBP9 levels in APP/PS1 mice. (a and b) Hippocampal extracts from 8-month-old WT and littermate APP/PS1 mice immunoblotted for the indicated proteins. (a) Representative blots showing a robust increase in endogenous RanBP9 protein together with overexpression of human APP (6E10 antibody). (b) Quantitation of endogenous RanBP9 protein levels in WT and APP/PS1 hippocampus normalized to WT (t-test, **P=0.0016, n=4 mice per genotype, 2 F and 2 M). (c) Representative immunohistochemical images of endogenous RanBP9 immunostaining within the dentate gyrus (DG) and CA3 of the hippocampus