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. 2015 Mar 12;6(3):e1687. doi: 10.1038/cddis.2015.47

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Copyright © 2015 Macmillan Publishers Limited

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Models depicting SPOP-mediated ERα degradation in physiological and pathological conditions in endometrial cancer. (a) Unmutated SPOP promotes degradation of wild-type ERα. (b) Endometrial cancer-associated mutants of SPOP are defective in promoting ERα ubiquitination and degradation. (c) Estrogen potentiates SPOP-mediated ERα degradation