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. 2015 Mar 5;6(3):e1672. doi: 10.1038/cddis.2015.49

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Copyright © 2015 Macmillan Publishers Limited

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International Licence. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons licence, users will need to obtain permission from the licence holder to reproduce the material. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0

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ISRIB is not toxic to the pancreas, unlike GSK2606414. (a) GSK2606414 treatment (green bar) mildly raises blood glucose levels compared with control (black bar), vehicle-treated (gray bar) and ISRIB-treated (blue bar) mice (n=6–9 for each group). (b) GSK2606414 treatment leads to a significant reduction in pancreas weight, while ISRIB treatment has no effect (n=3–6 for each group). (c) Representative images of hematoxylin and eosin-stained pancreas sections. GSK2606414 treatment leads to extensive destruction of exocrine acinar pancreatic tissue, while ISRIB-treated tissue is histologically normal. Scale bar=200 μm. *P<0.05, ***P<0.001, Student's t-test, two-tailed. Bar graphs show mean values±S.E.M.