Figure 2.

Prognostic significance of KLF4 and KLF5 in human breast cancer. Kaplan–Meier analysis utilized a previously described breast cancer microarray database.⁴⁰ Red (hi) and blue (lo) groups were defined using the median gene expression level within the tumors of breast cancer patients. A total of 364 luminal A, 175 luminal B, 239 HER2-enriched and 287 basal-like/claudin-low tumors were analyzed. (a) KLF4/5 were analyzed as single variables for all tumors combined. (b) KLF4/5 were analyzed as single variables within the basal-like/claudin-low and the HER2-enriched groups, as defined by PAM50 subtyping. (c) The outcome of patients harboring tumors with higher expression levels of both KLF4 and KLF5 (red, hi-hi) was compared with the outcome when tumors had lower expression levels of each factor (blue, lo-lo). For all curves, significance was determined using the log-rank (Mantel–Cox) test and P<0.05 was considered significant