Table 3. Association between genetic markers and overall survival in pazopanib-treated patients in discovery study 1.
| Gene | Polymorphism | rs Number | Minor Allele Frequency, % | P valuea | HRa (95% CI) |
|---|---|---|---|---|---|
| CYP3A4 | −392A>G | rs2740574 | G 4.8 | 0.5 | 0.78 (0.39–1.55) |
| CYP3A5 | 6986A>G | rs776746 | A 11.8 | 0.98 | 1.00 (0.68–1.45) |
| NR1I2 | −25385C>T | rs3814055 | T 39.0 | 0.02 | 1.34 (1.04–1.73) |
| NR1I2 | 7635A>G | rs6785049 | G 40.6 | 0.7 | 0.96 (0.74–1.24) |
| NR1I2 | 10620C>T | rs1054190 | T 9.0 | 0.7 | 1.11 (0.71–1.73) |
| ABCB1 | 1236C>T | rs1128503 | T 43.2 | 0.054 | 1.25 (1.00–1.58) |
| ABCB1 | 2677G>T/A (A893S/T) | rs2032582 | T/A 45.4 | 0.3 | 1.14 (0.89–1.47) |
| ABCB1 | 3435C>T | rs1045642 | T 47.7 | 0.1 | 1.22 (0.94–1.58) |
| ABCG2 | 34G>A (V12M) | rs2231137 | A 9.0 | 0.5 | 0.85 (0.55–1.33) |
| ABCG2 | 421C>A (Q141K) | rs2231142 | A 13.5 | 0.7 | 1.06 (0.74–1.53) |
| ABCG2 | 869C>T (Q126X) | rs72552713 | T 0.4 | 0.03b | 4.81 (1.15–20.18) |
| VEGFA | −2578A>C | rs699947 | C 47.9 | 0.2 | 0.85 (0.66–1.09) |
| VEGFA | −1498C>T | rs833061 | T 47.7 | 0.2 | 0.85 (0.66–1.09) |
| VEGFA | −1154G>A | rs1570360 | A 33.5 | 0.09 | 1.25 (0.96–1.63) |
| VEGFA | −634G>C | rs2010963 | C 27.8 | 0.2 | 0.83 (0.62–1.11) |
| VEGFA | 936C>T | rs3025039 | T 15.3 | 0.4 | 1.15 (0.82–1.62) |
| VEGFR2 | −604T>C | rs2071559 | C 43.5 | 0.4 | 0.90 (0.70–1.14) |
| VEGFR2 | 889G>A (V297I) | rs2305948 | A 8.9 | 0.4 | 1.20 (0.77–1.86) |
| VEGFR2 | 1416A>T (Q472H) | rs1870377 | T 22.6 | 0.3 | 0.86 (0.64–1.16) |
| VEGFR3 | 1480A>G (T494A) | rs307826 | G 8.6 | 0.2 | 1.36 (0.85–2.19) |
| PDGFRα | −573G>T | rs1800812 | T 21.7 | 0.3 | 0.86 (0.66–1.13) |
| IL8 | 2767A>T | rs1126647 | T 42.8 | 0.007 | 1.45 (1.11–1.91) |
| IL8 | −251T>A | rs4073 | A 49.8 | 0.02 | 1.36 (1.04–1.76) |
| FGF2 | 224C>T | rs1449683 | T 8.8 | 0.3 | 1.29 (0.78–2.12) |
| FGFR2 | IVS2 +906C>T | rs2981582 | T 38.8 | 0.008 | 1.40 (1.09–1.81) |
| HIF1α | 1772C>T (P582S) | rs11549465 | T 10.3 | 0.6 | 0.88 (0.58–1.34) |
| HIF1α | 1790G>A (A588T) | rs11549467 | A 3.2 | 0.6 | 0.84 (0.42–1.65) |
Abbreviations: CI=confidence interval; HR=hazard ratio.
a
The HR and P values were from additive genetic models. The P values were nominal values without adjustment for the number of SNPs tested; HR values represent the per variant allele allelic HR.
b
Although the ABCG2 rs72552713 was nominally significantly associated with overall survival, this association was driven by the only two patients with the variant CT genotype, and thus was not further discussed in this manuscript.