Table 4. Correlation between changes from baseline to C1D28 in soluble protein and cellular biomarkers (monocytes and CEC).
| VEGF | sVEGFR-2 | sVEGFR-3 | IL-8 | SDF-1α | |
|---|---|---|---|---|---|
|
VEGFR-1+ monocytes | |||||
| Spearman correlation coefficient | –0.25275 | –0.23956 | 0.51648 | –0.07253 | 0.21818 |
| P-value | 0.4048 | 0.4094 | 0.0586 | 0.8054 | 0.5192 |
| Sample size | 13 | 14 | 14 | 14 | 11 |
|
CXCR4+ monocytes | |||||
| Spearman correlation coefficient | 0.09341 | –0.35824 | 0.01538 | 0.57802 | 0.31818 |
| P-value | 0.7615 | 0.2085 | 0.9584 | 0.0304 | 0.3403 |
| Sample size | 13 | 14 | 14 | 14 | 11 |
|
CEP | |||||
| Spearman correlation coefficient | –0.01408 | 0.01657 | 0.35360 | 0.71272 | –0.30277 |
| P-value | 0.9653 | 0.9571 | 0.2359 | 0.0063 | 0.3655 |
| Sample size | 12 | 13 | 13 | 13 | 11 |
|
CEC | |||||
| Spearman correlation coefficient | 0.49650 | –0.61538 | –0.57692 | –0.05495 | 0.57273 |
| P-value | 0.1006 | 0.0252 | 0.0390 | 0.8585 | 0.0655 |
| Sample size | 12 | 13 | 13 | 13 | 11 |
Abbreviations: CEC=circulating endothelial cell; CEP=circulating endothelial progenitor cell; SDF-1α=stromal cell-derived factor 1α; VEGFR-1+=vascular endothelial growth factor receptor. Correlation coefficients with P-values ⩽0.05 are shown in bold.