Table 1. Associations of occupational exposures to endocrine disruptors and risk of mature B-cell neoplasms.
Overall |
Men |
Women |
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---|---|---|---|---|---|---|---|---|---|---|
Controls (n=2457) | Cases (n=1720) | OR (95% CI) | Controls (n=1317) | Cases (n=962) | OR (95% CI) | Controls (n=1140) | Cases (n=758) | OR (95% CI) | p-interaction | |
Ever held a job with exposure to any endocrine disruptor | ||||||||||
Unlikelya | 901 | 588 | Ref | 358 | 247 | Ref | 543 | 341 | Ref | |
Possible (never probable) | 591 | 438 | 1.11 (0.93,1.32) | 386 | 286 | 1.16 (0.92,1.46) | 205 | 152 | 1.03 (0.79,1.34) | 0.89 |
Probable | 838 | 633 | 1.07 (0.91,1.26) | 551 | 415 | 1.10 (0.87,1.39) | 287 | 218 | 1.04 (0.82,1.33) | |
Never workedb | 115 | 51 | 0.72 (0.50,1.03) | 15 | 6 | 1.05 (0.39,2.82) | 100 | 45 | 0.67 (0.45,1.00) | |
Age at first exposurec | ||||||||||
<15 | 466 | 379 | 1.12 (0.92,1.36) | 307 | 254 | 1.19 (0.91,1.55) | 159 | 125 | 1.04 (0.77,1.40) | 0.96 |
15–19 | 576 | 421 | 1.12 (0.94,1.34) | 393 | 280 | 1.15 (0.91,1.46) | 183 | 141 | 1.09 (0.83,1.43) | |
20+ | 383 | 269 | 1.05 (0.87,1.28) | 235 | 166 | 1.06 (0.81,1.38) | 148 | 103 | 1.04 (0.78,1.39) | |
P-trendd | 0.50 | 0.51 | 0.78 | |||||||
Time since last exposurec | ||||||||||
Current | 338 | 237 | 1.29 (1.04,1.60) | 262 | 189 | 1.39 (1.06,1.83)* | 76 | 48 | 1.12 (0.75,1.66) | 0.91 |
<14 | 428 | 319 | 1.12 (0.92,1.36) | 321 | 241 | 1.13 (0.88,1.45) | 107 | 78 | 1.11 (0.79,1.55) | |
15+ | 658 | 512 | 1.01 (0.86,1.20) | 351 | 270 | 0.99 (0.78,1.27) | 307 | 242 | 1.02 (0.80,1.31) | |
P-trendd | 0.01 | 0.01 | 0.50 | |||||||
Total years of exposure to endocrine disruptorsc | ||||||||||
<10 | 551 | 341 | 0.98 (0.82,1.18) | 297 | 170 | 0.97 (0.75,1.26) | 254 | 171 | 0.97 (0.76,1.25) | 0.38 |
10–29 | 460 | 352 | 1.17 (0.97,1.41) | 302 | 213 | 1.13 (0.87,1.46) | 158 | 139 | 1.23 (0.93,1.64) | |
30+ | 409 | 374 | 1.24 (1.01,1.51) | 332 | 317 | 1.32 (1.03,1.70)* | 77 | 57 | 0.98 (0.67,1.45) | |
P-trend | 0.02 | 0.02 | 0.46 |
Abbreviations: CI=confidence interval; OR=odds ratio. *P<0.05.
Reference category for all comparisons. All models were adjusted for age, education, sex, and country.
Participants who uniquely held occupations described as unemployment, retirement, student, family work (housewifes), or illness.
Probable and possible exposures to endocrine disruptors are combined.
Among exposed.