Table 2. Duration of exposures to endocrine disruptors and risk of mature B-cell neoplasms. Estimates for 10 years increase of occupational exposure to endocrine disruptors.
|
Overall |
Men |
Women |
||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Total years of exposure to | Controls | Cases | ORa (95% CI) | Controls | Cases | ORa (95% CI) | Controls | Cases | ORa (95% CI) | p-interaction |
| Unexposeda | 901 | 588 | Ref | 358 | 247 | Ref | 543 | 341 | Ref | |
|
Pesticides | ||||||||||
| Organochlorines | 442 | 347 | 1.10 (1.00,1.20)* | 275 | 227 | 1.13 (1.02,1.26)* | 167 | 120 | 1.00 (0.85,1.17) | 0.13 |
| Carbamates/pyrethroids | 507 | 391 | 1.11 (1.02,1.21)* | 337 | 268 | 1.15 (1.04,1.27)** | 170 | 123 | 0.99 (0.84,1.16) | 0.11 |
| Organophosphates | 467 | 366 | 1.10 (1.01,1.20)* | 297 | 245 | 1.14 (1.03,1.26)* | 170 | 121 | 1.00 (0.85,1.17) | 0.11 |
|
Organic Solvents | ||||||||||
| Ethylene glycol ethers | 943 | 719 | 1.06 (1.00,1.12)* | 595 | 454 | 1.08 (1.01,1.16)* | 348 | 265 | 1.01 (0.92,1.12) | 0.34 |
| Styrene | 38 | 33 | 0.96 (0.67,1.39) | 27 | 21 | 1.05 (0.65,1.70) | 11 | 12 | 0.90 (0.49,1.62) | 0.74 |
| Toluene/xylene | 735 | 565 | 1.05 (0.99,1.11) | 504 | 389 | 1.08 (1.00,1.16)* | 231 | 176 | 0.97 (0.87,1.09) | 0.18 |
| Trichloroethylene | 320 | 222 | 1.00 (0.90,1.11) | 262 | 181 | 1.01 (0.90,1.14) | 58 | 41 | 0.97 (0.71,1.34) | 0.94 |
| Perchloroethylene | 315 | 223 | 1.00 (0.90,1.12) | 254 | 175 | 1.01 (0.89,1.14) | 61 | 48 | 1.04 (0.76,1.43) | 0.73 |
|
Alkylphenolic compounds | ||||||||||
| Alkylphenolic ethoxylates | 736 | 578 | 1.07 (1.00,1.15)* | 393 | 298 | 1.11 (1.02,1.22)* | 343 | 280 | 1.01 (0.90,1.13) | 0.40 |
| Alkylphenols | 466 | 379 | 1.06 (0.98,1.16) | 285 | 238 | 1.12 (1.01,1.24)* | 181 | 141 | 0.94 (0.81,1.10) | 0.12 |
|
Metals | ||||||||||
| Cadmium | 108 | 77 | 0.90 (0.69,1.19) | 62 | 64 | 0.89 (0.66,1.20) | 16 | 13 | 0.89 (0.35,2.25) | 0.67 |
| Arsenic | 78 | 80 | 1.06 (0.87,1.30) | 99 | 72 | 1.05 (0.85,1.29) | 9 | 8 | 2.10 (0.61,7.20) | 0.27 |
| Copper | 824 | 617 | 1.07 (1.00,1.14)* | 583 | 433 | 1.10 (1.02,1.19)* | 241 | 184 | 0.97 (0.84,1.11) | 0.14 |
| Lead | 508 | 383 | 1.03 (0.95,1.12) | 432 | 336 | 1.06 (0.97,1.16) | 76 | 51 | 0.77 (0.55,1.08) | 0.09 |
| Mercury | 14 | 6 | 1.27 (0.84,1.93) | 6 | 5 | 1.25 (0.77,2.02) | 4 | 1 | 1.15 (0.47,2.79) | 0.72 |
Abbreviations: CI=confidence interval; OR=odds ratio. *P<0.05; **P<0.01.
a
Reference category for all comparisons. All models were adjusted for age, education, sex, country and ever exposure to organic solvents (except for estimates on organic solvents).