Fig. 3.

Stat1 deficiency exacerbates CD8⁺ T cell-mediated lung injury. A: survival of WT and Stat1^−/− HA-transgenic mice after adoptive transfer of 2.5 × 10⁶ HA210-specific WT CD8⁺ T cells. B: representative hematoxylin-eosin-stained whole lung histology 5 days after transfer of 2.5 × 10⁶ HA210-specific WT CD8⁺ T cells into WT (top) or Stat1^−/− (middle) HA-transgenic mice or transfer of 2.5 × 10⁶ HA210-specific GKO CD8⁺ T cells into Stat1^−/− HA-transgenic mice (bottom). C: BALF concentration of albumin 48 h after CD8⁺ T cell transfer. Values are means ± SD of 3 independent experiments with 2–4 mice per group.