Table 2.
Summary of BK V1/2 and differences in V1/2 values in different phosphorylation states
| LTH |
NX |
NX-LTH V1/2 Diff |
||||
|---|---|---|---|---|---|---|
| Phosphorylation State | Adult | Fetus | Adult | Fetus | Adult | Fetus |
| Native | 22.0 ± 6.5 (8) | 20.5 ± 4.9 (6) | 58.4 ± 5.4* (11) | 51.5 ± 3.9* (16) | 36.4 | 31.0 |
| Dephosphorylated | 25.3 ± 5.2 (8) | 23.6 ± 6.1 (7) | 67.3 ± 6.6* (12) | 64.1 ± 4.9* (14) | 42.0 | 40.5 |
| PKA | −32.6 ± 6.2 (8) | −35.3 ± 5.6 (6) | 3.3 ± 6.5* (14) | −1.2 ± 5.0* (15) | 35.9 | 34.1 |
| PKG | −22.8 ± 5.5 (9) | −25.9 ± 7.0 (6) | 20.6 ± 4.5* (11) | 14.9 ± 4.9* (11) | 43.4 | 40.8 |
Values are means ± SE, based on a sample size of (n). V1/2 values were obtained from BK channel voltage-activation curves at each phosphorylation state. Values for native controls, dephosphorylation, PKA, and PKG phosphorylation states were obtained from Fig. 3. NX-LTH V1/2 diff values show BK V1/2 differences between LTH and NX animal groups. When compared against LTH counterparts:
*
P < 0.05.