Table 1.
Cerebral and peripheral hemodynamic parameters at baseline and 4 selected time points during the thigh cuff maneuver
| Parameter | BSL | Pre-REL | REL5 | REL20 | REL40 | P Value ANOVA |
|---|---|---|---|---|---|---|
| MAP, mmHg | 95.0 (23.2) | 97.0 (24.8) | 76.8 (27.0)a | 87.4 (28.6) | 91.0 (25.4) | 0.00001 |
| Heart rate, beats/min | 61.4 (7.3) | 60.9 (5.7) | 65.7 (4.6) | 66.7 (6.0)b | 60.5 (6.2) | 0.0085 |
| ETCO2, mmHg | 37.7 (3.9) | 37.8 (4.3) | 37.8 (4.1) | 39.0 (3.9)c | 38.4 (3.0) | N.S. |
| CBFV, cm/s | ||||||
| R | 49.5 (10.5) | 48.7 (8.4) | 43.4 (10.1)a | 48.2 (7.1)d | 48.0 (7.4)d | 0.0010 |
| L | 53.1 (10.7) | 52.9 (10.0)d | 47.2 (10.8)a | 52.9 (9.9) | 52.9 (10.2) | 0.0002 |
| RAP, mmHg·s·cm−1 | ||||||
| R | 1.65 (0.52)e | 1.75 (0.52) | 1.43 (0.39)a | 1.55 (0.47) | 1.62 (0.47) | 0.0013 |
| L | 1.58 (0.55) | 1.66 (0.60) | 1.39 (0.60)a | 1.52 (0.68) | 1.56 (0.68) | 0.0100 |
| CrCP, mmHg | ||||||
| R | 14.7 (10.3) | 12.5 (12.9) | 14.6 (8.6) | 13.2 (11.1) | 11.7 (12.8) | N.S. |
| L | 14.1 (11.5) | 12.5 (10.9) | 13.7 (8.6) | 10.4 (12.8) | 10.7 (11.8) | N.S. |
| ARI | ||||||
| R | 4.7 (2.0) | 2.9 (1.6) | 3.9 (1.9) | 6.7 (1.3)f | 4.6 (2.2) | 0.00058 |
| L | 4.4 (1.9) | 3.0 (1.6) | 2.8 (1.3) | 6.5 (1.7)f | 4.6 (1.9) | 0.00037 |
Values are means (SD). MAP, mean arterial blood pressure; ETCO2, end-tidal CO2; CBFV, cerebral blood flow velocity; RAP, resistance area product; CrCP, critical closing pressure; ARI, dynamic cerebral autoregulation index; R, right middle cerebral arteries (MCA); L, left MCA; BSL, baseline; pre-REL, 3 s before thigh cuff (THC) release; REL5, 5 s after THC release; REL20, 20 s after THC release; REL40, 40 s after THC release.
P < 0.01, post hoc Tukey's test compared with pre-REL.
P < 0.05, post hoc Tukey's test compared with REL40.
P < 0.05, paired t-test compared with REL5.
P < 0.05, post hoc Tukey's test compared with REL5.
P < 0.05, post hoc Tukey's test compared with REL5.
P < 0.01, post hoc Tuckey's test compared with pre-REL and REL5.