Fig. 5.
Pretreatment with cyclosporine H (CsH, FPR-1 antagonist), WRW4 (FPR-2 antagonist), NG-nitro-l-arginine methyl ester (l-NAME; NOS inhibitor), 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one (ODQ; guanylyl cyclase inhibitor), 1400W (iNOS inhibitor), or basophil depletion blocked F-MIT-induced hypotension. A: representative tracing and arrows show F-MIT infusion. B, C, and E: average of the values of blood pressure (in mmHg). D: guanylyl cyclase activity (GC) in plasma. Means ± SE; n = 4–8. One-way ANOVA: *P < 0.05 vs. basal; t-test, +P < 0.05 vs. Veh.