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. Author manuscript; available in PMC: 2016 Jan 22.
Published in final edited form as: Prostaglandins Other Lipid Mediat. 2015 Jan 22;0:49–56. doi: 10.1016/j.prostaglandins.2015.01.001

Figure 4. Increased leukocyte accumulation in Atf3-deficient mice is associated with the Ptgs2/IL-17 axis.

Figure 4

(A) Levels of Ptgs2 mRNA in leukocytes obtained from inflammatory exudates of WT and Atf3-deficient mice undergoing peritonitis (4h). (B) Levels of PGE2/D2, inflammatory cytokines and chemokines IL-6, IL-1β, Cxcl1, Ccl3, and Ccl4, and leukotriene B4 (LTB4) in peritoneal exudates of WT and Atf3-deficient mice collected 4h after zymosan administration. (C) Expression of Alox5, Alox5 activating protein (ap) and Il-1β mRNA in WT or Atf3-deficient resident peritoneal macrophages stimulated with zymosan for 6h. (D) Levels of IL-17 in peritoneal exudates of WT and Atf3-deficient mice undergoing peritonitis (4h). Results are mean ± SEM, n=3–8/group. *P<0.05