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. 2015 Mar 29;8:14. doi: 10.1186/s12920-015-0088-y

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© Herrer et al.; licensee BioMed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Hypothetical model of the transcriptional regulatory network in ICM patients. Expression of the TFs, CITED2, CEBPD and BCL3, and SP100 is downregulated under conditions of hypoxia and other stress stimuli, which in turn modifies the expression of their target gene networks. These changes ultimately result in alterations in cellular processes that are characteristic of ICM.