Table-II.
Associated of IL-18 genotypes with risk of IS
| IL-18 polymorphism | Cases | % | Controls | % | p value | OR(95%CI) 1 |
|---|---|---|---|---|---|---|
| -607A/C genotype | ||||||
| AA | 54 | 16.77 | 71 | 22.05 | - | 1.0(Ref.) |
| AC | 180 | 55.9 | 183 | 56.83 | 0.22 | 1.29(0.84-1.99) |
| CC | 88 | 27.33 | 68 | 21.12 | 0.03 | 1.70(1.03-2.81) |
| Allele | ||||||
| A | 288 | 44.72 | 325 | 50.47 | - | 1.0(Ref.) |
| C | 356 | 55.28 | 319 | 49.53 | 0.04 | 1.26(1.01-1.58) |
| -137C/G genotype | ||||||
| CC | 11 | 3.42 | 18 | 5.59 | - | 1.0(Ref.) |
| CG | 81 | 25.16 | 84 | 26.09 | 0.27 | 1.58(0.66-3.94) |
| GG | 230 | 71.43 | 220 | 68.32 | 0.17 | 1.71(0.75-4.10) |
| Allele | ||||||
| C | 103 | 15.99 | 120 | 18.63 | - | 1.0(Ref.) |
| G | 541 | 84.01 | 524 | 81.37 | 0.21 | 1.20(0.89-1.62) |
1. Adjusted for sex, age, BMI, diabetes, hypertension, smoking and drinking