Table 2.
Key characteristics according to histopathologic diagnosis sorted by patient age at time of biopsy
| Histopathologic Diagnosis | No. of Patients N (%) | Genetic cause N/Ninfo (%) | At First Biopsy | IIT Responsiveness | ESRD at Last Observation (%) | ||||
|---|---|---|---|---|---|---|---|---|---|
| Agea (yr) | Serum Albumin (g/dl) | Hypertension (%) | eGFRa (ml/min per 1.73 m2) | Partial Remission N/Ninfo (%) | Complete Remission N/Ninfo (%) | ||||
| CNS | 8 (0.6) | 3/7 (43.0) | 0.2 (0.2–0.7) | 1.4 (0.4) | 0.0 | 56 (29–98) | 0/1 (0.0) | 0/1 (0.0) | 57.1 |
| DMS | 39 (2.9) | 22/35 (62.9) | 1.3 (0.6–2.3) | 2.0 (0.8) | 26.3 | 59 (37–97) | 0/10 (0.0) | 1/10 (10.0) | 72.2 |
| MCN | 283 (21.1) | 24/195 (12.3) | 4.2 (2.4–7.6) | 2.5 (1.0) | 15.8 | 108 (86–155) | 41/202 (20.3) | 103/202 (51.0) | 12.9 |
| MesPGN | 166 (12.4) | 23/123 (18.7) | 4.4 (2.4–8.4) | 2.4 (1.0) | 15.1 | 118 (84–162) | 26/101 (25.7) | 41/101 (40.6) | 18.9 |
| FSGS | 752 (56.0) | 122/555 (22.0) | 6.2 (3.0–11.0) | 2.7 (1.0) | 18.9 | 97 (68–142) | 93/469 (19.8) | 183/469 (39.0) | 30.9 |
| GGS | 17 (1.3) | 4/12 (33.3) | 6.6 (3.4–9.1) | 2.8 (0.8) | 17.7 | 17 (10–85) | 0/3 (0.0) | 1/3 (33.3) | 68.8 |
| MN | 11 (0.8) | 0/11 (0.0) | 7.0 (2.7–13.6) | 2.4 (0.9) | 27.3 | 116 (103–138) | 3/10 (30.0) | 5/10 (50.0) | 9.1 |
| MPGN | 35 (2.6) | 4/25 (16.0) | 10.5 (5.8–11.9) | 2.9 (0.8) | 22.9 | 112 (61–148) | 4/16 (25.0) | 6/16 (37.5) | 23.5 |
| Other | 31 (2.3) | 9/27 (33.3) | 8.8 (3.2–11.7) | 2.7 (1.1) | 6.7 | 45 (29–98) | 4/16 (25.0) | 6/16 (37.5) | 24.1 |
Information on genetic disease, features at first biopsy, IIT responsiveness, and fraction of ESRD at last observations refers to diagnosis by initial biopsy. Data are given as number (%), mean (SD), or median (interquartile range). CNS, Finnish-type congenital nephrotic syndrome; DMS, diffuse mesangial sclerosis; MCN, minimal change nephropathy; MesPGN, mesangioproliferative GN; GGS, global glomerulosclerosis; MN, membranous nephropathy; MPGN, membranoproliferative GN; Ninfo, number of patients with reported information.
a
Median (interquartile range).