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. 2015 Mar 18;112(13):4062–4067. doi: 10.1073/pnas.1503696112

Fig. 1.

Fig. 1.

Recurrent somatic mutation in YY1 in insulinomas. (A) Sanger sequencing of matched germ-line and tumor genomic DNA of YY1 codons 371–373. Forward and reverse sequences are shown, confirming the T372R mutation identified by exome sequencing. (B) Sanger sequencing of tumor cDNA of YY1 codons 371–373. Forward and reverse sequences are shown, demonstrating expression of the YY1T372R mutant allele. (C) Representation of the crystal structure of the third YY1 zinc finger domain bound to DNA at the wild-type binding sequence. The threonine at residue 372 (magenta) lies between an arginine at residue 371 and a histidine at residue 373 (both cyan), which directly contact DNA at the recognition motif. Projection of the YY1T372R side chain is shown (Right).