Fig. 2.

Altered YY1^T372R DNA-binding motif imparts a unique expression signature. (A) Motifs enriched by ChIP-seq following expression of YY1^WT and YY1^T372R in HEK293T cells compared with the published YY1^WT motif. Sites at which R371 and H373 of YY1^WT contact the DNA backbone between bases of the recognition motif are indicated by blue and orange arrows, respectively. (B) Expression profiles of YY1^T372R-harboring tumors (red) are distinct from those with YY1^WT (blue). Expression of all probes on the microarray for each tumor was used as input for unsupervised clustering by PCA.