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View of the editing site of TtPheRS representing interactions with puromycin and orthoester: (A) The protein residues participating in direct and water-mediated contacts with puromycin and (B) the protein residues participating in direct and water mediated contacts with cyclic orthoester acid 2′,3′-intermediate of the phenylalanine. Dashed lines show direct and water-mediated H bonds. The water molecules are depicted by blue spheres. Residues are numbered as in the PDB entry 1PYS.
