Fig. 3.

(A) Probability that the cell switches to the silenced state following cold as a function of population-averaged H3K27me3 NR peak level for digital and analog models. Plots start at the basal level of H3K27me3 present in all simulated nonvernalized cells in the nucleation region and end at maximum H3K27me3 nucleation level. (B) Experimental H3K27me3 NR peak profile as function of cold exposure duration (red dashed line and data points, as in Fig. 2). Solid blue line is simulated H3K27me3 NR peak profile, making the analog model as effective as the digital class 1 model.