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. 2014 Nov;34(21):3939–3954. doi: 10.1128/MCB.00457-14

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FIG 7 — FAN1 degrades nascent DNA strands at APH-stalled replication forks in the absence of FANCD2. Lengths of nascent replication fork tracts indicating fork stability (labeled with DigU only) were measured before (NT) and after 6 h of APH treatment. Preformed DigU tract lengths shortened during APH treatment in FANCD2-deficient (PD20) cells compared to wild-type (PD20+D2) cells (A) but not in FANCD2-FAN1-double-deficient (PD20, siFAN1) cells compared to wild-type (PD20+D2) cells (B). (C) Preformed DigU tract lengths do not shorten in FAN1-deficient (PD20+D2, siFAN1) cells. (Insets) Plotted median tract lengths.