Goal 1: Promote Human Health	To expand knowledge of the molecular and physiological mechanisms governing the normal function of HLBS systems as essential elements for sustaining human health.
Goal 2: Reduce Human Disease	To extend our knowledge of the pathobiology of HLBS disorders and enable clinical investigations that advance the prediction, prevention, preemption, treatment, and cures of human diseases.
Goal 3: Advance Translational Research	To facilitate innovation and accelerate research translation, knowledge dissemination, and implementation science that enhances public health.
Goal 4: Develop Workforce and Resources	To develop and enable a diverse biomedical workforce equipped with the essential skills and research resources to pursue emerging opportunities in science.

Note. HLBS = heart, lung, blood, and sleep. The Strategic Goals supporting the National Heart, Lung, and Blood Institute mission encompass understanding human health and disease, translating basic research into preventive and therapeutic interventions, and developing a biomedical workforce with the necessary skills and tools for HLBS research.