TABLE 3—

The Longitudinal Separate and Joint Associations of Obesity t_x and Major Depression t_x With High Work Performance Impairment t_x+1: Netherlands Study of Depression and Anxiety, 2004-2013

	High Work Performance Impairmenta
Predictors	OR (95% CI)	AORb (95% CI)	Additivity RERI (95% CI)c	Multiplicativity OR (95% CI)d
General obesity and major depression
Nonobese and nondepressed	1.00 (Ref)	1.00 (Ref)
Obesity (BMI ≥ 30 kg/m2)	1.39* (1.07, 1.80)	1.31* (1.01, 1.70)
Major depression	1.62* (1.31, 1.99)	1.59* (1.29, 1.96)
Both obese and major depression	2.57* (1.77, 3.74)	2.36* (1.61, 3.44)	0.57 (–0.46, 1.60)	1.15 (0.71, 1.85)
Abdominal obesity and major depression
Nonobese and nondepressed	1.00 (Ref)	1.00 (Ref)
Abdominal obesitye	1.39* (1.14, 1.70)	1.29* (1.05, 1.58)
Major depression	1.77* (1.40, 2.24)	1.74* (1.37, 2.20)
Both obese and major depression	2.07* (1.55, 2.78)	1.88* (1.40, 2.53)	−0.09 (–0.79, 0.61)	0.84 (0.57, 1.24)

Note. AOR = adjusted odds ratio; CI = confidence interval; OR = odds ratio; RERI = relative excess risk due to interaction.

^aReference: low work performance impairment.

^bAdjusted for age, gender, and educational status at baseline.

^eWaist circumference ≥ 102 cm for men and ≥ 88 cm for women.

^cDeparture from additivity; RERI = OR₁₁−OR₁₀−OR₀₁+1 = 2.57–1.39–1.62+1 = 0.57.

^dDeparture from multiplicativity; OR₁₁/(OR₁₀ × OR₀₁) = 2.57/(1.62 × 1.39) = 1.15.

*P < .05.