Table 1.
Characteristics of women with unilateral ductal carcinoma in situ (DCIS) in the SEER 18 Cancer Registries, 1988–2009, stratified by race and ethnicitya (n = 102,489)
| No. of patients (%) | |||||
|---|---|---|---|---|---|
| White | Black | Asian/PI | Hispanic | Pb | |
| Total | 75,431 (73.6) | 9,921 (9.7) | 9,246 (9.0) | 7,891 (7.7) | – |
| Age at diagnosis, y | |||||
| Mean (SD) | 59.1 (12.1) | 57.6 (12.0) | 56.0 (11.6) | 56.0 (11.7) | <0.0001 |
| 20–39 | 2,505 (3.3) | 512 (5.2) | 457 (4.9) | 378 (4.8) | – |
| 40–49 | 16,182 (21.5) | 2,267 (22.9) | 2,598 (28.1) | 2,262 (28.7) | – |
| 50–59 | 21,165 (28.1) | 2,881 (29.0) | 2,787 (30.1) | 2,320 (29.4) | – |
| 60–69 | 18,181 (24.1) | 2,384 (24.0) | 2,001 (21.6) | 1,733 (22.0) | – |
| ≥70 | 17,398 (23.1) | 1,877 (18.9) | 1,403 (15.2) | 1,198 (15.2) | <0.0001 |
| Length of follow-up, months | |||||
| Mean (range) | 82.6 (6,263) | 72.2 (6,263) | 77.4 (6,263) | 69.8 (6,263) | <0.0001 |
| 6–11 | 3,743 (5.0) | 625 (6.3) | 560 (6.1) | 556 (7.1) | – |
| 12–59 | 27,131 (36.0) | 4,174 (42.1) | 3,663 (39.6) | 3,437 (43.6) | – |
| 60–119 | 28,301 (37.5) | 3,534 (35.6) | 3,130 (33.9) | 2,731 (34.6) | – |
| ≥120 | 16,256 (21.6) | 1,588 (16.0) | 1,893 (20.5) | 1,167 (14.8) | <0.0001 |
| Year of the first DCIS diagnosisc | |||||
| 1988–1989 | 1,915 (2.5) | 179 (1.8) | 157 (1.7) | 75 (1.0) | – |
| 1990–1994 | 7,374 (9.8) | 720 (7.3) | 721 (7.8) | 488 (6.2) | – |
| 1995–1999 | 11,946 (15.8) | 1,411 (14.2) | 1,545 (16.7) | 1,004 (12.7) | – |
| 2000–2004 | 28,284 (37.5) | 3,589 (36.2) | 3,173 (34.2) | 2,847 (36.1) | – |
| 2005–2009 | 25,912 (34.4) | 4,022 (40.5) | 3,650 (39.5) | 3,477 (44.1) | <0.0001 |
| Histological subtype | |||||
| Not otherwise specified | 50,510 (67.0) | 6,795 (68.5) | 6,319 (68.3) | 5,394 (68.4) | – |
| Comedo | 11,523 (15.3) | 1,293 (13.0) | 1,174 (12.7) | 1,025 (13.0) | – |
| Papillary | 4,397 (5.8) | 820 (8.3) | 545 (5.9) | 509 (6.5) | – |
| Cribiform | 5,616 (7.5) | 662 (6.7) | 814 (8.8) | 657 (8.3) | – |
| Solid | 3,385 (4.5) | 351 (3.5) | 394 (4.3) | 306 (3.9) | <0.0001 |
| Grade | |||||
| Well differentiated | 7,432 (14.2) | 1,185 (17.2) | 990 (13.9) | 785 (13.1) | – |
| Moderately differentiated | 20,688 (39.4) | 2,866 (41.6) | 2,978 (41.7) | 2,553 (42.7) | – |
| Poorly differentiated | 24,356 (46.4) | 2,847 (41.3) | 3,173 (44.4) | 2,636 (44.1) | <0.0001 |
| Missing | 22,955 | 3,023 | 2,105 | 1,917 | – |
| Tumor size, cm | |||||
| <2.0 | 39,429 (78.9) | 4,519 (72.8) | 5,052 (72.2) | 3,838 (72.0) | – |
| 2.0–4.9 | 8,326 (16.7) | 1,233 (19.9) | 1,592 (22.8) | 1,160 (21.8) | – |
| ≥5.0 | 2,235 (4.5) | 456 (7.4) | 350 (5.0) | 335 (6.3) | <0.0001 |
| Missing | 25,441 | 3,713 | 2,252 | 2558 | – |
| Estrogen receptor | |||||
| Negative | 5,624 (18.4) | 684 (15.0) | 728 (18.3) | 631 (18.1) | – |
| Positive | 25,013 (81.6) | 3,882 (85.0) | 3251 (81.7) | 2855 (81.9) | <0.0001 |
| Missing | 44,794 | 5,355 | 5267 | 4405 | – |
| Surgery for first DCIS | |||||
| None | 1,599 (2.1) | 277 (2.8) | 121 (1.3) | 212 (2.7) | – |
| BCSd | 53,644 (71.4) | 6,685 (67.7) | 6,265 (68.0) | 5,638 (71.7) | – |
| Mastectomye | 19,927 (26.5) | 2,915 (29.5) | 2,828 (30.7) | 2,010 (25.6) | <0.0001 |
| Missing | 261 | 44 | 32 | 31 | – |
| Radiation therapy for first DCIS | |||||
| No | 40,506 (54.7) | 5,546 (56.9) | 5,053 (55.3) | 4,308 (55.7) | – |
| Yes | 33,556 (45.3) | 4,200 (43.1) | 4,081 (44.7) | 3,425 (44.3) | 0.0003 |
| Missing | 1,369 | 175 | 112 | 158 | – |
| Surgery and radiation therapy for first DCIS | |||||
| No surgery | 1,599 (2.2) | 277 (2.8) | 121 (1.3) | 212 (2.7) | – |
| BCSd alone | 19,852 (26.8) | 2,506 (25.7) | 2,176 (23.9) | 2,183 (28.2) | – |
| BCSd and radiation | 32,787 (44.2) | 4,064 (41.6) | 3,998 (43.8) | 3,324 (43.0) | – |
| Mastectomye | 19,927 (26.9) | 2,915 (29.9) | 2,828 (31.0) | 2,010 (26.0) | <0.0001 |
| Missing | 1,266 | 159 | 123 | 162 | – |
SD standard deviation, BCS breast-conserving surgery
Race and ethnicity were classified into mutually exclusive categories of non-Hispanic white (hereafter referred to as white), non-Hispanic black (black), non-Hispanic Asian or Pacific Islander (Asian/PI), and Hispanic (Hispanic)
P values were calculated from a comparison across all groups except the groups with missing values
Cases diagnosed between 1988 and 1989 were from nine registries (Atlanta, Connecticut, Detroit, Hawaii, Iowa, New Mexico, San Francisco-Oakland, Seattle-Puget Sound, and Utah). Cases diagnosed between 1990 and 1999 were from 12 registries (the above nine registries, plus Los Angeles, San Jose-Monterey, and Rural Georgia). Cases diagnosed since 2000 were from 17 registries (the above 12 registries, plus Greater California, Kentucky, Louisiana, New Jersey, and Greater Georgia). Cases from the Alaska Native Tumor Registry were excluded due to the small number of Alaskan Native patients
Breast-conserving surgery consisted of excisional biopsy, lumpectomy, nipple resection, wedge resection, quadrantectomy, segmental mastectomy, tylectomy, and partial mastectomy, NOS
Mastectomy included total mastectomy, modified radical mastectomy, radical mastectomy, subcutaneous mastectomy and mastectomy, not otherwise specified