Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2015 Mar 27;4(3):e34. doi: 10.1038/cti.2015.2

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2015 Australasian Society for Immunology Inc.

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

PMC Copyright notice

Longitudinal analysis of thymic and central naive CD4⁺ T cells and Treg subsets. (a) Longitudinal flow analysis of thymic, central naive and memory CD4⁺ populations as a percentage of CD4⁺ T cells (n=130 repeated measures, line graph with mean±95% CI). There was a minor drop (P<0.0001) in thymic naive CD4⁺ T cells between birth and 6 months, and a further decrease, from 6 to 12 months. There was a drop in central naive CD4⁺ T cells (P<0.0001) between birth and 6 months, but no change in percentage between 6 and 12 months (P=0.18). The CD4⁺ T-cell memory population increased (P<0.0001)) from birth to 6 months with a further increase to 12 months (P<0.0001). (b) Longitudinal analysis of FoxP3⁺ CD4⁺ T-cell subsets during the first year of life expressed as a percentage of CD4⁺ T cells (n=130 repeated measures, line graph with mean±95% CI). There was a marked increase (P<0.0001) in rTreg from birth to 6 months, and then a slight reduction between 6 and 12 months (P<0.032). There was a greater than twofold increase (P<0.0001) in both aTreg and activation-induced FoxP3⁺ CD4⁺ T cells from birth to 6 months, and a further increase in both populations (P<0.0001) between 6 and 12 months.