Table 1. Mean percentages (with 95% CIs) of T-cell subtypes during the first year of life (n=130 infants).
| Cell populations |
First year of life |
|||||
|---|---|---|---|---|---|---|
|
Birth |
6 months |
12 months |
||||
| Mean (%) | 95% CI | Mean (%) | 95% CI | Mean (%) | 95% CI | |
| As % of lymphocytes | ||||||
| CD3+ T cells | 59.3 | 57.6, 61.1 | 64.7 | 63.5, 65.8 | 64.1 | 62.9, 65.3 |
| CD4+ T cells | 42.7 | 41.3, 44.2 | 45.2 | 44.1, 46.3 | 41.6 | 40.4, 42.7 |
| As % of CD4+ T cells | ||||||
| CD45RA+ naïve | 93.5 | 93.1, 93.8 | 84.1 | 83.3, 84.8 | 78.3 | 77.4, 79.3 |
| CD31+ thymic naïve | 76.1 | 75.2, 77.1 | 73.1 | 72.3, 74.0 | 67.1 | 66.0, 68.2 |
| CD31− central naïve | 17.4 | 16.5, 18.2 | 10.9 | 10.3, 11.5 | 11.2 | 10.5, 11.9 |
| CD45RA−/CD31− memory | 4.1 | 3.9, 4.4 | 10.7 | 10.2, 11.2 | 15.7 | 15.0, 16.5 |
| rTreg, CD45RA+FoxP3low | 4.1 | 3.9, 4.3 | 5.6 | 5.4, 5.8 | 5.3 | 5.0, 5.6 |
| aTreg, CD45RA−FoxP3high | 0.72 | 0.66, 0.79 | 1.46 | 1.32, 1.59 | 1.91 | 1.72, 2.10 |
| Activation-induced FoxP3 T cells (CD45RA−FoxP3low) | 0.53 | 0.53, 0.63 | 1.78 | 1.63, 1.92 | 2.65 | 2.48, 2.83 |
Abbreviations: aTreg, activated T regulatory cell; CI, confidence interval; rTreg, resting T regulatory cell.