Table 5.
Cytochrome P450 3A4 Inhibitors
| Amiodarone (Cordarone) |
| Aprepitant (Emend) |
| Atazanavir (Reyataz) |
| Caffeine |
| Cimetidine (Tagamet) |
| Clarithromycin (Biaxin) |
| Clotrimazole (Mycelex) |
| Conivaptan (Vaprisol) |
| Cyclosporine (Sandimmmune) |
| Delavirdine (Rescriptor) |
| Desipramine (Norpramin) |
| Diltiazem (Cardizem) |
| Doxycycline (Vibramycin) |
| Efavirenz (Sustiva)* |
| Erythromycin (e.g., E-mycin) |
| Fluconazole (Diflucan) |
| Fosamprenavir (Lexiva) |
| Fosaprepitant (Emend) |
| Fospropofol (Lusedra) |
| Haloperidol (Haldol) |
| Imatinib (Gleevec) |
| Indinavir (Crixivan) |
| Isoniazid (e.g., Nydrazid) |
| Itraconazole (Sporanox) |
| Ketoconazole (Nizoral) |
| Lidocaine (Xylocaine) |
| Metronidazole (Flagyl) |
| Miconazole (Monistat) |
| Nefazodone (Serzone) |
| Nelfinavir (Viracept) |
| Nicardipine (Cardene) |
| Norfloxacin (Noroxin) |
| Posaconazole (Noxafil) |
| Propofol (Diprivan) |
| Quinidine |
| Ritonavir (Norvir) |
| Saquinavir (Invirase) |
| Sertraline (Zoloft) |
| Sitaxsentan (Thelin) |
| Telithromycin (Ketek) |
| Tetracycline (e.g., Sumycin) |
| Verapamil (e.g., Calan) |
| Voriconazole (Vfend) |
Adapted with permission from Lacy C, et al. Drug Information Handbook, 19th ed. 2010:1724–1730.9
*
Efavirenz is considered both a cytochrome P450 3A4 inhibitor and inducer.