Table 2.
The relationships between LRAT promoter methylation status and clinical features in CRCs
| Tumor (CpG 1–6)
|
p value | Adjacent normal (CpG 1–6)
|
p value | |||
|---|---|---|---|---|---|---|
| Hypermethylated | Unmethylated | Hypermethylated | Unmethylated | |||
| Location | ||||||
| Distal | 39 | 42 | 5 | 32 | ||
| Proximal | 20 | 22 | 0.96 | 7 | 25 | 0.36 |
| Gender | ||||||
| Male | 29 | 30 | 4 | 29 | ||
| Female | 30 | 34 | 0.8 | 11 | 25 | 0.06 |
| Age | ||||||
| <55 | 8 | 20 | 0 | 15 | ||
| 55–64 | 17 | 13 | 4 | 13 | ||
| 65–70 | 14 | 13 | 2 | 11 | ||
| 71–85 | 20 | 18 | 0.13 | 6 | 18 | 0.07 |
| AJCC stage | ||||||
| I | 12 | 8 | ||||
| II | 17 | 8 | ||||
| III | 15 | 18 | ||||
| IV | 15 | 30 | 0.03 | |||
| Differentiation | ||||||
| Well | 0 | 1 | ||||
| Moderate | 48 | 52 | ||||
| Poor | 7 | 5 | ||||
| No info | 4 | 6 | 0.73 | |||
| Mucinous histology | ||||||
| No | 37 | 47 | ||||
| Yes | 18 | 12 | ||||
| No info | 4 | 5 | 0.32 | |||
| Mutations | ||||||
| K-ras | 23 | 18 | ||||
| B-raf | 3 | 2 | ||||
| WT | 33 | 44 | 0.31 | |||