Fig 2. Management of newborns born to women with lesions at delivery and no history of genital herpes prior to pregnancy.
* For newborns with CNS/disseminated disease, treat for 21 days and 14 days for newborns with SEM disease. For babies with CNS involvement, repeat CSF analysis and CSF HSV PCR prior to stopping treatment. If CSF has detectable DNA by PCR at the end of therapy, continue treatment until negative CSF PCR result. After completion of parenteral therapy, treat with oral acyclovir suppressive therapy for 6 months (300mg/m2/dose three times per day).